Understanding Macrophage Interaction with Antimony-Doped Tin Oxide Plasmonic Nanoparticles.
Olexiy A BalitskiiViktoriya IvasivMaria Porteiro-FigueirasPhattadon YajanMira WitzigAura Maria Moreno-EcheverriJosé Muñetón DíazBarbara Rother-RutishauserAlke Petri-FinkSandeep KeshavanPublished in: Cells (2024)
Antimony-doped tin oxide nanoparticles (ATO NPs) have emerged as a promising tool in biomedical applications, namely robust photothermal effects upon near-infrared (NIR) light exposure, enabling controlled thermal dynamics to induce spatial cell death. This study investigated the interplay between ATO NPs and macrophages, understanding cellular uptake and cytokine release. ATO NPs demonstrated biocompatibility with no impact on macrophage viability and cytokine secretion. These findings highlight the potential of ATO NPs for inducing targeted cell death in cancer treatments, leveraging their feasibility, unique NIR properties, and safe interactions with immune cells. ATO NPs offer a transformative platform with significant potential for future biomedical applications by combining photothermal capabilities and biocompatibility.
Keyphrases
- oxide nanoparticles
- cell death
- photodynamic therapy
- drug release
- cancer therapy
- quantum dots
- adipose tissue
- drug delivery
- fluorescence imaging
- cell cycle arrest
- highly efficient
- papillary thyroid
- human health
- visible light
- squamous cell carcinoma
- metal organic framework
- atomic force microscopy
- current status
- climate change
- squamous cell
- risk assessment
- tissue engineering
- high resolution
- signaling pathway
- energy transfer
- high speed