Nalmefene Prevents Alcohol-Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4.
Jorge MontesinosAnabel GilConsuelo GuerriPublished in: Alcoholism, clinical and experimental research (2017)
These results suggest that NF prevents neuroinflammation and brain damage by blocking the TLR4 response and also support the role of central pro-inflammatory immune signaling in the modulation of alcohol consumption/addiction.
Keyphrases
- alcohol consumption
- lps induced
- inflammatory response
- toll like receptor
- lipopolysaccharide induced
- cerebral ischemia
- nuclear factor
- oxidative stress
- immune response
- traumatic brain injury
- young adults
- diabetic rats
- high glucose
- mental health
- cognitive impairment
- mouse model
- signaling pathway
- resting state
- high fat diet induced
- subarachnoid hemorrhage
- type diabetes
- brain injury
- pi k akt
- functional connectivity
- endothelial cells
- insulin resistance
- cell proliferation