Porous Titanium Scaffolds with Mechanoelectrical Conversion and Photothermal Function: A Win-Win Strategy for Bone Reconstruction of Tumour-Resected Defects.

Bone metastases severely threaten the lives of patients. Although surgical treatment combined with adjuvant chemotherapy significantly improves the survival rate of patients, tumour recurrence or metastasis after surgical resection and bone defects caused by surgical treatment remain major challenges for clinicians. Given the abovementioned clinical requirements, barium titanate-containing iron-coated porous titanium alloy scaffolds have been proposed to promote bone defect repair and inhibit tumour recurrence. Fortunately, in vitro and in vivo experimental research confirmed that barium titanate containing iron-coated porous titanium alloy scaffolds promoted osteogenesis and bone reconstruction in defect repair via mechanoelectric conversion and inhibited tumour recurrence via photothermal effects. Furthermore, the underlying and intricate mechanisms of bone defect repair and tumour recurrence prevention of barium titanate-containing iron-coated porous titanium alloy scaffolds were explored. A win-win strategy for mechanoelectrical conversion and photothermal functionalisation provides promising insights into bone reconstruction of tumour-resected defects. This article is protected by copyright. All rights reserved.