The potential mechanism of the progression from latent to active tuberculosis based on the intestinal microbiota alterations.

Dan LuoChong-Yu ShiNian-Sa WeiBo-Yi YangKai QinGang LiuBai-Qing DongYi-Xiang QinXiao-Ling QinShi-Yi ChenXiao-Jing GuoLi GanRuo-Lan XuHai LiJing Li

Published in: Tuberculosis (Edinburgh, Scotland) (2023)

Our study indicated that from LTBI to ATB, some intestinal microbiota inhibit the synthesis of interferon (INF)-γ and interleukin (IL)-17, promoting the survival and spread of Mycobacterium tuberculosis (M. tb). In addition, the metabolites secreted by intestinal microbiota and dysbiosis in intestine also have an effect on the development of LTBI to ATB.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
ms ms
dendritic cells
risk assessment
free survival
human health
climate change
human immunodeficiency virus
hiv infected