Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an exploratory study.
Shannon S ConnardAngela M GaesserEmily J ClarkeRenata L LinardiKayla M EvenJulie B EngilesDrew W KochMandy J PeffersKyla F OrtvedPublished in: Journal of the American Veterinary Medical Association (2024)
We have identified dynamic molecular changes in the small noncoding signatures of plasma and synovial fluid EVs in horses with naturally occurring PTOA. These findings could serve to identify promising biomarkers in the pathogenesis of PTOA, to facilitate the development of targeted therapies, and to aid in establishing appropriate translational models of PTOA.