Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats.

Adam KimbroughJenni KononoffSierra SimpsonMarsida KallupiSharona SedighimKenia PalominoDana ConliskJeremiah D MomperGiordano de GuglielmoOlivier George

Published in: Psychopharmacology (2020)

The present study demonstrated the face validity of the extended access model of oxycodone self-administration by identifying sex differences in the escalation of oxycodone intake and pronounced changes in pain and affective states.

Keyphrases

chronic pain
bipolar disorder
pain management
clinical trial
weight gain
spinal cord
physical activity