Outcomes of Patients with Metastatic Colorectal Cancer Treated with Trifluridine/Tipiracil beyond the Second Line: A Multicenter Retrospective Study from Saudi Arabia.
Mohammed AlghamdiShouki BazarbashiMervat MahrousOmar AlshaerAhmed Mostafa GadMohamed AseafanMai AbdelgelilRedhwan Mohammed AlshabiHosam Ali AlghanmiNasser Ahmed NaserHusam Al HaririAbdulaziz ALHamadKhalid Al-SalehNashwa M Abdel AzizSherif ElsamanyPublished in: Journal of oncology (2022)
Treatment with FTD/TPI is feasible and effective in daily clinical practice in Saudi Arabian patients. The risk of progression increased with advanced disease stage, lymph node metastasis, bone metastasis, and metastasis to >2 sites. Age ≥ 55 years, advanced disease stage, liver metastasis, metastasis to >2 sites, neutropenia after the first cycle of FTD/TPI, and increased number of FTD/TPI cycles were independent factors predicting mortality.
Keyphrases
- metastatic colorectal cancer
- saudi arabia
- lymph node metastasis
- clinical practice
- end stage renal disease
- newly diagnosed
- squamous cell carcinoma
- ejection fraction
- chronic kidney disease
- physical activity
- clinical trial
- papillary thyroid
- prognostic factors
- cardiovascular events
- risk factors
- body composition
- cardiovascular disease
- insulin resistance
- skeletal muscle
- soft tissue
- metabolic syndrome
- replacement therapy
- combination therapy
- smoking cessation