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Canonical and noncanonical functions of complement in systemic lupus erythematosus.

Matthew Caleb PickeringMarina Botto
Published in: European journal of immunology (2024)
For many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissue damage. A hierarchy is apparent with early classical pathway components, particularly C1q, exerting the greatest influence. Understanding the mechanisms underlying the protective function(s) of complement remains an important challenge for the future and has implications for the use of complement therapy in SLE. We review recent advances in the field and give a new perspective on the complement conundrum in SLE.
Keyphrases
  • systemic lupus erythematosus
  • endothelial cells
  • stem cells
  • oxidative stress
  • rheumatoid arthritis
  • magnetic resonance
  • magnetic resonance imaging
  • diffusion weighted imaging
  • case control