Targeting Src SH3 domain-mediated glycolysis of HSC suppresses transcriptome, myofibroblastic activation, and colorectal liver metastasis.

Yuanguo WangXianghu WangBing Bai Aurpita Shaha Xipu HeYingzi HeZhenqing YeVijay H ShahNingling Kang

Published in: Hepatology (Baltimore, Md.) (2024)

The Src SH3 domain-facilitated metabolic reprogramming induced by TGFβ1 represents a target to inhibit CAF activation and the pro-metastatic liver microenvironment.

Keyphrases

tyrosine kinase
stem cells
gene expression
genome wide
rna seq
single cell
transforming growth factor
cancer therapy