ADAMTS13 regulation of VWF multimer distribution in severe COVID-19.

Soracha E WardHelen FogartyEllie KarampiniMichelle LavinSonja SchneppenheimRita DittmerHannah MorrinSiobhan GlaveyCliona Ni CheallaighColm BerginIgnacio Martin-LoechesPatrick W MallonGerard F CurleyRoss I BakerUlrich BuddeJamie M O'Sullivan James S O'Donnellnull null

Published in: Journal of thrombosis and haemostasis : JTH (2021)

These findings support the hypothesis that SARS-CoV-2 is associated with profound quantitative and qualitative increases in plasma VWF levels, and a multifactorial down-regulation in ADAMTS-13 function. Further studies will be required to determine whether therapeutic interventions to correct ADAMTS-13-VWF multimer dysfunction may be useful in COVID-microvascular thrombosis and angiopathy.

Keyphrases

sars cov
coronavirus disease
respiratory syndrome coronavirus
pulmonary embolism
physical activity
oxidative stress
intellectual disability
early onset