Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner.

Kumar AbhishekSushmita DasAshish KumarAjay KumarVinod KumarSavita SainiAbhishek MandalSudha VermaManjay KumarPradeep Das

Published in: PLoS neglected tropical diseases (2018)

Overall the findings from the study suggests that Leishmania modulated host UPR and PERK phosphorylation delays apoptotic induction in host macrophage, hence supports parasite invasion at early stages of infection.

Keyphrases

endoplasmic reticulum stress
endoplasmic reticulum
cell death
adipose tissue
high glucose
cell proliferation
cell migration
protein protein
oxidative stress
plasmodium falciparum