A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma.
Michael C PetersLando RingelNathan DyjackRachelle HerrinPrescott G WoodruffCydney RiosBrian O'ConnorJohn V FahyMax A SeiboldPublished in: American journal of respiratory and critical care medicine (2020)
Persistent airway T2 inflammation is a complex construct of innate and adaptive immunity gene expression networks that are variable across individuals with asthma and persist despite steroid treatment. Individuals with T2-low asthma exhibit an airway deficiency in cytotoxic T cells associated with obesity-driven inflammation.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- oxidative stress
- gene expression
- allergic rhinitis
- immune response
- insulin resistance
- metabolic syndrome
- type diabetes
- weight loss
- cystic fibrosis
- air pollution
- single cell
- weight gain
- replacement therapy
- adipose tissue
- body mass index
- physical activity
- smoking cessation