Activation of Kv 7 channels as a novel mechanism for NO/cGMP-induced pulmonary vasodilation.

Gema Mondéjar-ParreñoJavier Moral-SanzBianca BarreiraAlicia De la CruzTeresa GonzalezMaria CallejoSergio Esquivel-RuizDaniel Morales-CanoLaura MorenoCarmen ValenzuelaFrancisco Perez-VizcainoÁngel Cogolludo

Published in: British journal of pharmacology (2019)

NO donors and riociguat enhance Kv 7 currents, leading to PASMC hyperpolarization. This mechanism contributes to NO/cGMP-induced PA vasodilation. Our study identifies Kv 7 channels as a novel mechanism of action of vasodilator drugs used in the treatment of pulmonary arterial hypertension.

Keyphrases

pulmonary arterial hypertension
pulmonary hypertension
high glucose
nitric oxide
pulmonary artery
diabetic rats
drug induced
image quality
protein kinase
dual energy
genome wide
gene expression
computed tomography
smoking cessation
stress induced