Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival.

Giulia CorradiCarmen BaldazziDarina OčadlíkováGiovanni MarconiSarah ParisiNicoletta TestoniCarlo FinelliMichele CavoAntonio CurtiMarilena Ciciarello

Published in: Stem cell research & therapy (2018)

Overall, our results elucidated that MDS-MSCs and AML-MSCs did not show macroscopic and/or tumor-related defects, but both displayed functional features potentially contributing to favor a leukemia-protective milieu.

Keyphrases

acute myeloid leukemia
bone marrow
allogeneic hematopoietic stem cell transplantation
mesenchymal stem cells
end stage renal disease
newly diagnosed
ejection fraction
peritoneal dialysis
umbilical cord
prognostic factors
acute lymphoblastic leukemia
patient reported outcomes
risk assessment
patient reported