Classification and regression tree-based prediction of 6-mercaptopurine-induced leucopenia grades in children with acute lymphoblastic leukemia.

Shaik Mohammad NaushadPatchava DorababuYedluri RupasreeAddepalli PavaniDigumarti RaghunadharaoTajamul HussainSalman A AlrokayanVijay Kumar Kutala

Published in: Cancer chemotherapy and pharmacology (2019)

TPMT *3C and TPMT*12 are the key determinants of 6-MP-mediated hematological toxicity while other variants of TPMT (int3, int4 and int7) and ITPA ex2 interact synergistically with TPMT*3C or TPMT*12 variant alleles to enhance the toxicity. TPMT and ITPA variants cumulatively are excellent predictors of 6-MP-mediated toxicity.

Keyphrases

acute lymphoblastic leukemia
oxidative stress
copy number
machine learning
young adults
deep learning
high glucose