Immunosuppressant indulges EBV reactivation and related lymphoproliferative disease by inhibiting Vδ2+ T cells activities after hematopoietic transplantation for blood malignancies.
Jiangying LiuHaitao GaoLan-Ping XuXiao-Dong MoRuoyang LiuShuang LiangNing WuMing WangZhidong WangYing-Jun ChangYu WangXiao-Hui ZhangXiao-Jun HuangPublished in: Journal for immunotherapy of cancer (2021)
These results elucidated a negative effect of immunosuppressants on the anti-EBV capacity of Vδ2+ T cells. Strategies that appropriately relieve the immunosuppression may improve anti-EBV immunity by increasing the activity of Vδ2+ T cells after alloHCT.