ADME pharmacogenetics: future outlook for Russia.
Karin B MirzaevDenis S FedorinovDmitry V IvashchenkoDmitry A SychevPublished in: Pharmacogenomics (2019)
This systematic review reflects the results of pharmacogenetic studies in the Russian Federation aimed at studying the genes involved in the drug biotransformation system. The works of Russian researchers found by us are mostly devoted to microsomal liver oxidation enzymes (metabolism) and membrane transporter systems (absorption and excretion). This review presents population-ethnic and associative clinical studies on the genes of the CYP450 system, noncytochrome oxidation enzymes (SULT1A1, CES1), membrane transporter system genes (ABCB1, SLCO1B1) and warfarin biotransformation enzymes (VKORC1, GGCX). The information is structured in the form of 11 tables, divided by regions of the Russian Federation.
Keyphrases
- systematic review
- genome wide
- hydrogen peroxide
- meta analyses
- atrial fibrillation
- bioinformatics analysis
- genome wide identification
- venous thromboembolism
- molecular docking
- healthcare
- direct oral anticoagulants
- genome wide analysis
- emergency department
- dna methylation
- health information
- transcription factor
- molecular dynamics simulations