Role of Inflammation in Depressive and Anxiety Disorders, Affect, and Cognition: Genetic and Non-Genetic Findings in the Lifelines Cohort Study.
Naoise Mac GiollabhuiChloe SlaneyGibran HemaniÉimear M FoleyPeter J van der MostIlja Maria NolteHarold SniederGeorge Davey SmithGolam M KhandakerCatharina A HartmanPublished in: medRxiv : the preprint server for health sciences (2024)
Genetic and non-genetic analyses provide consistent evidence for an association between CRP and negative affect. Genetic analyses suggest that IL-6 signaling could be relevant for memory, and that the association between CRP and anxiety disorders could be causal. These results suggest that dysregulated immune physiology may impact a broad range of trans-diagnostic affective symptoms. However, given the small effect sizes and multiple tests conducted, future studies are required to investigate whether effects are moderated by sub-groups and whether these findings replicate in other cohorts.