Autologous blood transfusion impedes glycolysis in macrophages to inhibit red blood cell injury in type 2 diabetes through PI3K/Akt/PKM2 signaling axis.

Yong ChengHuan WangNa YaoQin RenYu BaiLai-Wei YouXiao-Fei ChenJian-Rong Guo

Published in: Acta diabetologica (2023)

Autologous blood transfusion can reduce glycolysis in macrophages and inhibit the release of inflammatory factors through the PI3K/PKM2 signal axis, thereby inhibiting red blood cell damage and improving the oxygen-carrying capacity and survival activity of RBCs in diabetic patients.

Keyphrases

red blood cell
pi k akt
signaling pathway
type diabetes
cell cycle arrest
bone marrow
oxidative stress
cell therapy
cell proliferation
platelet rich plasma
cardiovascular disease
glycemic control
insulin resistance
cell death
free survival
metabolic syndrome
mesenchymal stem cells
weight loss