Exosome-transported circHDAC1_004 Promotes Proliferation, Migration, and Angiogenesis of Hepatocellular Carcinoma by the miR-361-3p/NACC1 Axis.

Bin XuWenbo JiaYanzhi FengJinyi WangJing WangDeming ZhuChao XuLitao LiangWenzhou DingYongping ZhouLian Bao Kong

Published in: Journal of clinical and translational hepatology (2023)

We found that circHDAC1_004 overexpression enhanced the proliferation, stemness, and metastasis of HCC via the miR-361-3p/NACC1 axis and promoted HCC angiogenesis through exosomes. Our findings may help develop a possible therapeutic strategy for HCC.

Keyphrases

endothelial cells
stem cells
signaling pathway
vascular endothelial growth factor
mesenchymal stem cells
cell proliferation
transcription factor
bone marrow