Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes.

Kameron B Rodrigues Matthew J DufortAlba LlibreCate SpeakeM Jubayer RahmanVincent BondetJuan QuielPeter S LinsleyCarla J GreenbaumDarragh DuffyKristin V Tarbell

Published in: Diabetologia (2020)

Mouse gene expression data are found in the gene expression omnibus (GEO) repository, accession GSE146452 ( www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146452 ). Nanostring count data from the human experiments were deposited in the GEO repository, accession GSE146338 ( www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146338 ). Data files and R code for all analyses are available at https://github.com/rodriguesk/T1D_truculture_diabetologia . Graphical abstract.

Keyphrases

gene expression
type diabetes
electronic health record
innate immune
dna methylation
big data
endothelial cells
cardiovascular disease
metabolic syndrome
insulin resistance
glycemic control
adipose tissue
weight loss
peripheral blood