Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study.
Meng WangZeneng WangYujin LeeHeidi T M LaiMarcia C de Oliveira OttoRozenn N LemaitreAmanda FrettsNona SotoodehniaMatthew J BudoffJoseph A DiDonatoBarbara McKnightWai Hong Wilson TangBruce M PsatyDavid S SiscovickStanley L HazenDariush MozaffarianPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.