Kaempferol Incorporated Bovine Serum Albumin Fibrous Films for Ocular Drug Delivery.
Chuanjin YinYalu LiuXueju QiChuanlong GuoXiaochen WuPublished in: Macromolecular bioscience (2021)
The possibility of using drug loaded bovine serum albumin (BSA) porous films as therapeutic contact lenses is investigated. Kaempferol (KAE), a hydrophobic antioxidant and anti-inflammatory agent, is incorporated into BSA porous films to form BSA/KAE films. The BSA/KAE films are transparent in the visible wavelength range of the human eye, possessing high water content and good cytocompatibility. A prolonged and sustained drug release is observed, and the in vivo efficacy of BSA/KAE films is better than the individual KAE. BSA/KAE films promoted the corneal re-epithelialization, inhibited neovascularization, and reduced the inflammation of an alkali burn induced corneal injury model. The study demonstrates the promising potential of BSA/KAE films as therapeutic contact lenses for the treatment of corneal injury, builds an available ocular drug delivery platform for ocular diseases.
Keyphrases
- drug delivery
- room temperature
- drug release
- carbon nanotubes
- anti inflammatory
- oxidative stress
- cancer therapy
- wound healing
- optical coherence tomography
- emergency department
- endothelial cells
- ionic liquid
- high throughput
- diabetic retinopathy
- high glucose
- risk assessment
- optic nerve
- induced pluripotent stem cells
- high speed