Functional Connectomics and Disease Progression in Drug-Naïve Parkinson's Disease Patients.

Rosa De MiccoFederica AgostaSilvia BasaiaMattia SicilianoCamilla CividiniGioacchino TedeschiMassimo FilippiAlessandro Tessitore

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

Our findings revealed that functional reorganization of the brain connectome occurs early in PD and underlies crucial involvement of striatal projections. Connectomic measures may be helpful to identify a specific PD patient subtype, characterized by severe motor and non-motor clinical burden as well as widespread functional connectivity abnormalities. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

functional connectivity
resting state
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
single cell
case report
early onset
emergency department
brain injury
blood brain barrier
patient reported