Asymmetric Palladium-Catalyzed Aminochlorination of Unactivated Alkenes.

A novel Pd-catalyzed enantioselective aminochlorination of alkenes via a 6- endo cyclization is reported herein, which provides easy access to a wide array of structurally diverse 3-chloropiperidines in good yields with excellent enantioselectivities. Notably, both an electrophilic chlorination reagent (NCS) and the sterically bulky chiral pyridinyl-oxazoline (Pyox) ligand are crucial to the successful reaction.