Cell cycle control in cancer.
Helen K MatthewsCosetta BertoliRobertus A M de BruinPublished in: Nature reviews. Molecular cell biology (2021)
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell cycle checkpoints operate as DNA surveillance mechanisms that prevent the accumulation and propagation of genetic errors during cell division. Checkpoints can delay cell cycle progression or, in response to irreparable DNA damage, induce cell cycle exit or cell death. Cancer-associated mutations that perturb cell cycle control allow continuous cell division chiefly by compromising the ability of cells to exit the cell cycle. Continuous rounds of division, however, create increased reliance on other cell cycle control mechanisms to prevent catastrophic levels of damage and maintain cell viability. New detailed insights into cell cycle control mechanisms and their role in cancer reveal how these dependencies can be best exploited in cancer treatment.
Keyphrases
- cell cycle
- cell proliferation
- induced apoptosis
- cell cycle arrest
- cell death
- dna damage
- single cell
- papillary thyroid
- oxidative stress
- cell therapy
- squamous cell
- gene expression
- squamous cell carcinoma
- public health
- endoplasmic reticulum stress
- lymph node metastasis
- patient safety
- transcription factor
- circulating tumor
- signaling pathway
- dna repair
- dna methylation
- copy number
- cell free
- electronic health record