A randomized clinical trial comparing physician-directed or fixed-dose steroid replacement strategies for incomplete dexamethasone dosing prior to docetaxel chemotherapy.

Tina HsuDean FergussonCarol StoberKelly DaigleNoorza MoledinaLisa VandermeerGreg PondJohn HiltonBrian HuttonMark Clemonsnull null

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2020)

While not meeting our predefined criteria of improving the time from randomization to starting docetaxel by 30 min, the fixed-dose replacement strategy reduced both the time to starting docetaxel and treatment variability. Fixed dosing with oral dexamethasone 8 mg should be the preferred standard of care. REGISTRATION: www.clinicaltrials.gov NCT02815319 REGISTRATION DATE: June 28, 2016.

Keyphrases

locally advanced
high dose
low dose
rectal cancer
healthcare
emergency department
primary care
palliative care
squamous cell carcinoma
radiation therapy
pain management
combination therapy
smoking cessation