Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation.
Maximiliano Ribeiro GuerraJuliette CoignardSéverine Eon-MarchaisMarie-Gabrielle DondonDorothée Le GalJuana BeauvalletNoura MebiroukMuriel BelottiOlivier CaronMarion Gauthier-VillarsIsabelle CoupierBruno BuecherAlain LortholaryJean-Pierre FrickerPaul GestaCatherine NoguèsLaurence FaivrePascaline BerthetElisabeth LuporsiCapucine DelnatteValérie BonadonaChristine M MaugardPascal PujolChristine LassetMichel LongyYves-Jean BignonClaude Adenis-LavignasseLaurence Venat-BouvetHélène DreyfusLaurence GladieffIsabelle MortemousqueSéverine Audebert-BellangerFlorent SoubrierSophie GiraudSophie Lejeune-DumoulinJean-Marc LimacherJean ChiesaAnne FajacAnne FloquetFrançois EisingerJulie TinatSandra Fert-FerrerChrystelle ColasThierry FrebourgFrancesca DamiolaLaure BarjhouxEve CavaciutiSylvie MazoyerAnne TardivonFabienne LesueurDominique Stoppa-LyonnetNadine AndrieuPublished in: Breast cancer research : BCR (2021)
Ever/never chest X-ray exposure increases BC risk 2-fold regardless of age at first exposure and, by up to 5-fold when carrying 3 or more rare variants in a DNA repair gene. Further studies are needed to evaluate other DNA repair genes or variants to identify those which could modify radiation sensitivity. Identification of subpopulations that are more or less susceptible to ionizing radiation is important and potentially clinically relevant.