Treprostinil Attains Clinically Therapeutic Concentrations in Neonates with Pulmonary Hypertension on Extracorporeal Membrane Oxygenation Support.

Felix Rafael De Bie Karel AllegaertHolly L HedrickNatalie E RintoulAlexander Davidson

Published in: Pharmacotherapy (2020)

CONCLUSIONS: THIS IS THE FIRST STUDY TO REPORT CLINICALLY THERAPEUTIC TREPROSTINIL CONCENTRATIONS IN CIRCULATING PLASMA AFTER TREPROSTINIL ADMINISTRATION IN NEONATES ON ECMO, WITH ASSOCIATED CLINICAL IMPROVEMENT OF PH AND NO SIGNS OF HEMODYNAMIC INSTABILITY.

Keyphrases

extracorporeal membrane oxygenation
pulmonary arterial hypertension
pulmonary hypertension
acute respiratory distress syndrome
pulmonary artery
respiratory failure
low birth weight
mechanical ventilation
intensive care unit