Dimethyl fumarate decreases neurofilament light chain in CSF and blood of treatment naïve relapsing MS patients.

Tobias SejbækHelle Hvilsted NielsenNatasha PennerTatiana PlavinaJason P MendozaNellie Anne MartinMaria Louise ElkjaerMads Henrik RavnborgZsolt Illes

Published in: Journal of neurology, neurosurgery, and psychiatry (2019)

This study provides Class II evidence that first-line DMF reduces NFL in both blood and CSF after 6 months and normalises CSF levels in 73% of patients. High NFL concentration in CSF after a year reflected disease activity. NFL levels were higher in serum than in plasma, which should be considered when NFL is used as a biomarker.

Keyphrases

disease activity
end stage renal disease
ejection fraction
rheumatoid arthritis
newly diagnosed
systemic lupus erythematosus
cerebrospinal fluid
combination therapy
replacement therapy