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Hydroxyapatite Block Produced by Sponge Replica Method: Mechanical, Clinical and Histologic Observations.

Antonio ScaranoFelice LorussoPablo Santos de OliveiraSanosh Kunjalukkal PadmanabhanAntonio Licciulli
Published in: Materials (Basel, Switzerland) (2019)
After the 3 months healing period, the histological outcome of the investigation showed a high level of biological osteoconduction of the HA. Microscopical evidence of new bone formation was also observed in the central portion of the graft block. The samples were composed of different tissues: 39 ± 1% new bone, 42 ± 3% marrow space, 17 ± 3% residual HA Block and 4.02 ± 2% osteoid tissue were present. The new bone formation in the block was 8 ± 3%. Conclusions: The study findings support that HA porous scaffolds produced by sponge replica were effective for the treatment of maxillary bone defects in humans.
Keyphrases
  • bone marrow
  • molecular dynamics
  • molecular dynamics simulations
  • tissue engineering
  • gene expression
  • mesenchymal stem cells
  • bone mineral density
  • combination therapy
  • soft tissue
  • cone beam computed tomography