Innate immune cells and myelin profile in multiple sclerosis: a multi-tracer PET/MR study.

Milena Sales PitombeiraMichel KooleKenia R CampanholoAline M SouzaFábio L S DuranDavi J Fontoura SollaMaria F MendesSamira L Apóstolos PereiraCarolina M RimkusGeraldo Filho BusattoDagoberto CallegaroCarlos A BuchpiguelDaniele de Paula Faria

Published in: European journal of nuclear medicine and molecular imaging (2022)

Widespread innate immune cells profile and marked loss of myelin in T<sub>2</sub> lesions and regions close to the ventricles may occur independently and are associated with disability, in both WM and GM structures.

Keyphrases

innate immune
multiple sclerosis
induced apoptosis
cell cycle arrest
white matter
computed tomography
positron emission tomography
endoplasmic reticulum stress
signaling pathway
pet imaging
high resolution
cell death
pet ct