Incidence of seropositive and seronegative rheumatoid arthritis in Denmark: a nationwide population-based study.

The IR of seropositive RA increased over time, whereas the IR of seronegative RA decreased. Temporal IR changes may be caused by a real change in the RA serology subtypes, an increase in autoantibody testing and availability, changes in registration practice over time, or a combination of these factors.