Association of prenatal alcohol exposure with offspring DNA methylation in mammals: a systematic review of the evidence.

Mitchell BestryMartyn SymonsAlexander LarcombeEvelyne MuggliJeffrey M CraigDelyse HutchinsonJane HallidayDavid J Martino

Published in: Clinical epigenetics (2022)

Considering heterogeneity in study design and potential for bias, evidence for an association between PAE and offspring DNA methylation was inconclusive. Some reproducible associations were observed in populations with FASD although the limited number of these studies warrants further research. Trail Registration: This review is registered with PROSPERO (registration number: CRD42020167686).

Keyphrases

dna methylation
genome wide
high fat diet
gene expression
pregnant women
alcohol consumption
insulin resistance
risk assessment
spectrum disorder