TNFα Blockade in Checkpoint Inhibition: The Good, the Bad, or the Ugly?

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

The impact on survival of steroids and TNFα blockade to treat immune-related toxicity from checkpoint blockade with ipilimumab, nivolumab/pembrolizumab, or combined ipilimumab and nivolumab was assessed using data from a large national database. Using steroids was associated with better survival than the use of TNFα-blocking antibodies such as infliximab.See related article by Verheijden et al., p. 2268.

Keyphrases

rheumatoid arthritis
dna damage
cell cycle
oxidative stress
free survival
electronic health record
quality improvement
advanced non small cell lung cancer
deep learning
data analysis
drug induced