Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate.
Yan LiYongying ZhouDaoquan LiuZhen WangJizhang QiuJunchao ZhangPing ChenGuang ZengYuming GuoXinghuan WangMichael E DiSantoXin-Hua ZhangPublished in: Journal of translational medicine (2023)
Our novel data manifested that GPX3, which was capable of inducing apoptosis via AMPK/ERK1/2 pathway and antagonizing autophagy-related ferroptosis through AMPK/m-TOR signalling, was a promising therapeutic target for BPH in the future.
Keyphrases
- cell death
- signaling pathway
- skeletal muscle
- endoplasmic reticulum stress
- cell cycle arrest
- oxidative stress
- cell proliferation
- protein kinase
- prostate cancer
- pi k akt
- benign prostatic hyperplasia
- diabetic rats
- drug induced
- electronic health record
- high glucose
- hydrogen peroxide
- endothelial cells
- big data
- deep learning