Pericyte modulation by a functional antibody obtained by a novel single-cell selection strategy.
Jesper JustSimon LykkemarkCharlotte H NielsenAli R RoshenasKim R DrasbekSteen V PetersenToke BekPeter KristensenPublished in: Microcirculation (New York, N.Y. : 1994) (2018)
The selection method provides an efficient platform for the selection of functional antibodies which target pericytes. We obtain an antibody that interacts with a fibronectin epitope important for pericyte mobility and functionality. Targeting of this epitope in pathologies where pericytes are implicated could potentially be of therapeutic benefit.