Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor-Associated Hypertension.

Zhe YeRyuji OkamotoHiromasa ItoRie ItoKeishi MoriwakiMizuki IchikawaLupiya Kimena Yusuf Ali Masaaki Ito Celso E Gomez-Sanchez Kaoru Dohi

Published in: Journal of the American Heart Association (2024)

Cardiac-specific MYPT2 knockout leads to decreased myosin light chain phosphatase and increased p-MLC. MYPT2 deletion prevented cardiac fibrosis and dysfunction in a model of mineralocorticoid receptor-associated hypertension.

Keyphrases

blood pressure
left ventricular
binding protein
oxidative stress
heart failure
atrial fibrillation