The effect of serum pretreatment regimens for the detection of HLA class I antibodies in platelet-refractory patients.

Gizem TumerThomas GniadekJennifer BayeRyan PenaPaul WarnerMark FungLynette BeaudinHeather DunckleyManish J GandhiBirgit GathofSusan HsuEllen KloheNalaja MarcusRoberta BamertShona SimsMinoko TakanashiSilvano WendelClaudia S Cohnnull null

Published in: Transfusion (2020)

Our results show that greater interlaboratory precision can be achieved when samples are pretreated with EDHI as opposed to no pretreatment, likely because these pretreatments eliminate interference from inhibitors. Inhibitors may mask antibodies, leading to missed (or uncalled) specificities when no pretreatment is used.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
patient reported outcomes