IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy.

Matthew GubermanRimpy DhingraJenna CrossVictoria MarguletsHongying GangInna Rabinovich-NikitinLorrie A Kirshenbaum

Published in: Cardiovascular research (2024)

The findings of this study reveal a novel survival pathway for IKKβ that is mutually dependent upon and obligatory linked to the phosphorylation and stabilization of the mitochondrial dynamics protein MFN2.

Keyphrases

heart failure
oxidative stress
signaling pathway
drug delivery
genome wide
gene expression
dna methylation
protein kinase
small molecule
atrial fibrillation