A viscoelastic adhesive epicardial patch for treating myocardial infarction.
Xiao LinYue LiuAobing BaiHuanhuan CaiYanjie BaiWei JiangHuilin YangXinhong WangLei YangNing SunHuajian GaoPublished in: Nature biomedical engineering (2019)
Acellular epicardial patches that treat myocardial infarction by increasing the mechanical integrity of damaged left ventricular tissues exhibit widely scattered therapeutic efficacy. Here, we introduce a viscoelastic adhesive patch, made of an ionically crosslinked transparent hydrogel, that accommodates the cyclic deformation of the myocardium and outperforms most existing acellular epicardial patches in reversing left ventricular remodelling and restoring heart function after both acute and subacute myocardial infarction in rats. The superior performance of the patch results from its relatively low dynamic modulus, designed at the so-called 'gel point' via finite-element simulations of left ventricular remodelling so as to balance the fluid and solid properties of the material.
Keyphrases
- left ventricular
- heart failure
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- finite element
- acute myocardial infarction
- left atrial
- aortic stenosis
- mitral valve
- hyaluronic acid
- atomic force microscopy
- liver failure
- drug delivery
- wound healing
- molecular dynamics
- atrial fibrillation
- respiratory failure
- breast reconstruction
- coronary artery disease
- intensive care unit
- drug induced
- hepatitis b virus
- mechanical ventilation
- aortic valve