Active maintenance of CD8 + T cell naïvety through regulation of global genome architecture.
Brendan E RussKirril TsyganovSara QuonBingfei YuJasmine LiJason K C LeeMoshe OlshanskyZhaohren HePaul F HarrisonAdele BarugahareMichael SeeSimone NussingAlison E MoreyVibha A UdupaTaylah J BennettAxel KalliesCornelis MurrePhillipe CollasDavid PowellAnanda W GoldrathStephen J TurnerPublished in: bioRxiv : the preprint server for biology (2023)
T cell differentiation states are underscored by distinct chromatin looping architectures. Chromatin loops juxtapose CTL state appropriate enhancers, transcription factors and genes.Effector and memory CTLs have similar genome architectures, explaining rapid memory recall.CTL differentiation is restrained by BACH2 and SATB1, which enforce a naïve loop architecture.