Even "WISE-R?"-an Update on the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation.
Lili BarskyC Noel Bairey MerzJanet WeiChrisandra ShufeltEileen HandbergCarl PepineThomas RutledgeSteven ReisMark DoyleWilliam RogersLeslee ShawGeorge SopkoPublished in: Current atherosclerosis reports (2020)
Women with symptoms and signs of ischemia but no significant epicardial obstructive coronary artery disease (INOCA) were documented to be at elevated risk for recurrent angina hospitalization, major adverse cardiac events, death, and health resource consumption rivaling those with obstructive coronary disease. WISE investigators have advanced our understanding of cardiovascular outcomes, systemic manifestations, psychological variables, socioeconomic factors, genetic contributions, hormonal status, advanced imaging, coronary functional findings, biomarkers, patient-reported outcomes, and treatments pertaining to women with this disease entity. This review delves into the WISE findings subsequent to a prior review1, postulates directions for future research, and asks are we "Even 'WISE-R?'".
Keyphrases
- coronary artery disease
- patient reported outcomes
- coronary artery
- percutaneous coronary intervention
- cardiovascular events
- polycystic ovary syndrome
- coronary artery bypass grafting
- public health
- healthcare
- mental health
- high resolution
- aortic stenosis
- left ventricular
- genome wide
- heart failure
- risk assessment
- emergency department
- dna methylation
- sleep quality
- cardiovascular disease
- acute coronary syndrome
- skeletal muscle
- photodynamic therapy
- health promotion
- drug induced
- transcatheter aortic valve replacement
- fluorescence imaging
- adverse drug
- clinical evaluation