Alpha-pinene modulates inflammatory response and protects against brain ischemia via inducible nitric oxide synthase-nuclear factor-kappa B-cyclooxygenase-2 pathway.
Mohammad ShabaniSohaila ErfaniArash AbdolmalekiFatemeh Ephtekhar AfzaliSeyedeh Mahdieh KhoshnazarPublished in: Molecular biology reports (2023)
Results showed that alpha-pinene protects the cerebral against ischemic damage caused by MCAO, and this effect may be through the regulating iNOS -NF-kappa B- COX-2 and caspase-3 inflammatory and apoptotic pathways.
Keyphrases
- nuclear factor
- nitric oxide synthase
- inflammatory response
- toll like receptor
- nitric oxide
- cell death
- cerebral ischemia
- oxidative stress
- lps induced
- subarachnoid hemorrhage
- lipopolysaccharide induced
- resting state
- white matter
- ischemia reperfusion injury
- brain injury
- anti inflammatory
- induced apoptosis
- immune response
- cerebral blood flow
- cell proliferation