Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus.

Takayuki SakaiSaori HattoriAya OgataTakashi YamadaJunichiro AbeHiroshi IkenumaMasanori IchiseMasaaki SuzukiKengo ItoTakashi KatoYasuyuki Kimura

Published in: EJNMMI research (2023)

C]MRB PET may be used as an in vivo biomarker of noradrenaline concentrations in the hippocampus of the neurodegenerating brain. Further studies appear warranted to extend its applicability to AD studies.

Keyphrases

cerebral ischemia
positron emission tomography
pet ct
computed tomography
case control
high glucose
pet imaging
cognitive impairment
diabetic rats
oxidative stress
prefrontal cortex
white matter
subarachnoid hemorrhage
blood brain barrier
endothelial cells
multiple sclerosis