Children with nut allergies have impaired gene expression of Toll-like receptors pathway.

Ashlyn PooleYong SongMichael O'SullivanKhui Hung LeeJessica MetcalfeJing GuoHelen BrownBen MullinsRichard LohGuicheng Brad Zhang

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2020)

Gene expression of TLR pathway genes was directly related to food allergy type, and DNA methylation had an indirect effect. TLR2 pathways are of significant interest in nut allergies.

Keyphrases

gene expression
dna methylation
genome wide
toll like receptor
inflammatory response
immune response
young adults
nuclear factor
copy number