Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.
Leo T M Van Der VenPaul Van OmmerenEdwin P ZwartEric R GremmerHennie M HodemaekersHarm J HeusinkveldJacob D van KlaverenEmiel RorijePublished in: Environmental health perspectives (2022)
This case study of a complex mixture inducing craniofacial malformations in zebrafish embryos shows that dose addition can adequately predicted the cumulative effect of a mixture of multiple substances at low doses, irrespective of the (expected) MOA. The applied workflow may be useful as an approach for CRA in general. https://doi.org/10.1289/EHP9888.
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