Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity.

Fulei Han Shuai Zhu Xiangjie Kong Weijing Wang Yili Wu

Published in: International journal of obesity (2005) (2023)

Not only the gene polymorphism, but also the DNA methylation of GLP1R was associated with MHO. Epigenetic changes in the methylome may in part explain the relationship between genetic variants and MHO.

Keyphrases

dna methylation
genome wide
gene expression
copy number
insulin resistance
metabolic syndrome
weight loss
type diabetes
weight gain
high fat diet induced
adipose tissue
skeletal muscle
body mass index