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The TMEM16A anion channel as a versatile regulator of vascular tone.

Paolo Tammaro
Published in: Science signaling (2023)
The TMEM16A channel represents a key depolarizing mechanism in arterial smooth muscle and contractile pericytes, where it is activated by several endogenous contractile agonists. In this issue of Science Signaling , Mata-Daboin et al. demonstrate a previously unidentified role for TMEM16A in endothelial cells for acetylcholine-mediated vasorelaxation. Collectively, TMEM16A serves as a transducer of vasoactive stimuli to enable fine modulation of vessel tone.
Keyphrases
  • smooth muscle
  • endothelial cells
  • skeletal muscle
  • public health