Effect of polygenic load on striatal dopaminergic deterioration in Parkinson disease.

Myung Jun LeeKyoungjune PakJong Hun KimYun Joong KimJeehee YoonJinwoo LeeChul Hyoung LyooHyung Jun ParkJae-Hyeok LeeNa-Yeon Jung

Published in: Neurology (2019)

Our results suggest that genetic factors for PD risk may have heterogeneous effects on striatal dopaminergic degeneration, and some factors may be associated with a slower decline of dopaminergic activity. Composition of PD progression-specific GRS may be useful in predicting disease progression in patients.

Keyphrases

parkinson disease
deep brain stimulation
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
functional connectivity
prognostic factors
peritoneal dialysis
gene expression